I got this error while working on BizTalk application development
Error Message: The published message could not be routed because no subscribers were found. This error occurs if the subscribing orchestration or send port has not been enlisted, or if some of the message properties necessary for subscription evaluation have not been promoted. Please use the Biztalk Administration console to troubleshoot this failure.
Solution i found
You would try to change the Receive pipeline to “XMLReceive”, instead of “PassThruReceive”, this way is worthy to try as one of the possibilities.